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. 2021 Feb 22;29(3):269–279. doi: 10.1016/j.jsps.2021.02.003

Table 1.

Independent variables and responses used for optimization of bilosomes.

Factor Level
Independent variables Low (−1) Medium (0) High (+1)
A: Cholesterol (CHO, %) 10 20 30
B: Surfactant (Span 60, %) 50 60 70
C: Bile Salt (Sodium deoxycholate, SDC) 10 15 20
Responses
Y1: Vesicle size (nm) Optimum
Y2: Entrapment efficiency (%) Maximize
Y3: Drug release (%) Maximize