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Independent variables and responses used for optimization of bilosomes.
| Factor |
Level |
||
|---|---|---|---|
| Independent variables | Low (−1) | Medium (0) | High (+1) |
| A: Cholesterol (CHO, %) | 10 | 20 | 30 |
| B: Surfactant (Span 60, %) | 50 | 60 | 70 |
| C: Bile Salt (Sodium deoxycholate, SDC) | 10 | 15 | 20 |
| Responses | |||
| Y1: Vesicle size (nm) | Optimum | ||
| Y2: Entrapment efficiency (%) | Maximize | ||
| Y3: Drug release (%) | Maximize | ||
