Table 3.

Statistical summary of each model for all responses predicted from statistical design software.

Vesicle size (Y1)
Source (Model)	R2	Adjusted R2	Predicted R2	Standard deviation	Coefficient of variance (%)	Remark
Linear	0.9574	0.9476	0.9161	9.12	---	---
2FI	0.9814	0.9703	0.9265	6.86	---	---
Quadratic	0.9999	0.9997	0.9996	0.69	0.37	Suggested
Entrapment efficiency (Y2)
Linear	0.9755	0.9698	0.9494	1.10	---	---
2FI	0.9931	0.9889	0.9680	0.67	---	---
Quadratic	0.9991	0.9980	0.9978	0.28	0.35	Suggested
Drug release (Y3)
Linear	0.9613	0.9524	0.9395	1.05	---	---
2FI	0.9644	0.9430	0.9019	1.15	---	---
Quadratic	0.9980	0.9954	0.9942	0.32	0.38	Suggested