Table 4.
Analysis of variance of response surface quadratic model of each response.
| Model | Source | Vesicle size (nm) | Encapsulation efficiency (%) | Drug release (%) |
|---|---|---|---|---|
| Quadratic | Sum of Squares | 25402.66 | 650.94 | 373.006 |
| df | 9 | 9 | 9 | |
| Mean Square | 2822.518 | 72.32 | 41.44 | |
| F- Value | 5811.195 | 868.50 | 393.03 | |
| P-value, Prob > F | < 0.0001 | < 0.0001 | < 0.0001 | |
| Remark | Suggested, Significant | |||
| Lack of fit | ||||
| Quadratic | Sum of Squares | 0.33 | 0.035425 | 0.068 |
| df | 3 | 3 | 3 | |
| Mean Square | 0.11 | 0.011808 | 0.02 | |
| F- Value | 0.14 | 0.086268 | 0.13 | |
| P-value, Prob > F | 0.92 | 0.96 | 0.93 | |
| Remark | Suggested, not significant | |||
| Residual | ||||
| Quadratic | Sum of Squares | 3.399925 | 0.582945 | 0.73814 |
| df | 7 | 7 | 7 | |
| Mean Square | 0.485704 | 0.083278 | 0.105449 | |