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Mean percentage change in bone mineral density (BMD) of the (A) lumbar spine, (B) total hip, and (C) femoral neck from baseline to 6 and 12 months depending on previous therapy. Bars indicate the mean ± standard errors. *P < 0.05, **P < 0.01, and ***P < 0.001 versus baseline (Wilcoxon's signed-rank test). †P < 0.05, ††P < 0.01, and †††P < 0.001 versus treatment-naïve group (Wilcoxon's rank-sum test).
