Fig. 2.

The conformational tuning of the MAX:MAX dimer in the DNA bound state. MD simulations could confirm NMR and EPR data that suggested strong backbone as well as side-chain motions of the DNA-binding site even in the DNA-bound state where the binding sites fold into a stable helical form. The simulations showed how the bound helices open and close continuously around the DNA-strand. (adapted from reference [63] with permission of the publisher.)