Fig. 3.

DNA binding of the Drosophila melanogaster transcription factor Brinker (BrkDBD) as an example for induced fit upon binding of TFs to their target DNA. The intrinsically disordered TF recruits the DNA and only folds into a helical state after the encounter complex has been formed. The protein binding region is marked in cyan. The black values indicate the timing required (and confidence bounds) for the various steps. (Adapted from reference [92] with permission of the publisher.) (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)