Table 3.
Short-term outcomes for 102 pediatric patients with acute osteomyelitis with and without abscess formation
| Bone abscess (n = 25) | Muscle abscess (n = 29) | Any abscess (n = 46) | No abscess (n = 56) | P-value for any vs. no abscess | |
|---|---|---|---|---|---|
| Number of event outcomes [n (%)]a,b | |||||
| Septic emboli | 3 (17) | 4 (22) | 6 (19) | 2 (5) | 0.131 |
| PICC required | 13 (54) | 16 (55) | 27 (60) | 18 (32) | 0.00513 |
| Number surgeries | 2 (1, 3) | 2 (1, 3) | 2 (1, 3) | <1 (0, 1) | < 0.00012 |
| Readmission/relapse | 5 (20) | 2 (7) | 6 (13) | 2 (4) | 0.141 |
| Readmission | 5 (20) | 2 (7) | 6 (13) | 2 (4) | - |
| Relapse | 3 (14) | 1 (4) | 4 (10) | 0 (0) | - |
| Imaging outcomes [median (Q1, Q3)]c | |||||
| Number of MRI’s ordered | 1 (1, 1) | 2 (1, 2) | 2 (1, 2) | 1 (1, 1) | 0.00082 |
| Number of radiographs ordered | 4 (3, 6) | 4 (3, 5) | 4 (3, 6) | 3 (2, 4) | 0.102 |
| Duration outcomes [median (Q1, Q3)]d | |||||
| Total duration antibiotics | 90 (56, 130) | 52 (45, 102) | 56 (47, 128) | 45 (42, 55) | 0.00042 |
| Total duration intravenous antibiotics | 23 (12, 52) | 24 (12, 47) | 29 (12, 50) | 9 (6, 31) | 0.00022 |
| Total duration oral antibiotics | 86 (35, 137) | 34 (12, 84) | 36 (23, 90) | 35 (14, 41) | 0.182 |
| Duration hospital stay (days) | 16 (12, 24) | 11 (9, 19) | 13 (10, 21) | 8 (6, 12) | < 0.00012 |
| Time to defervesence | 7 (2, 13) | 4 (3, 8) | 5 (2, 11) | 1 (0, 3) | < 0.00012 |
| Laboratory value outcomes [median (Q1, Q3)]e | |||||
| Maximum CRP (mg/dl) | 21.4 (13.2, 25.6) | 14.2 (8.3, 24.3) | 18.0 (10.1, 25.5) | 6.1 (2.8, 15.2) | 0.00022 |
| Maximum ESR (mm/h) | 87.5 (71.0, 123.5) | 96.0 (77.0, 115.0) | 88.0 (68.0, 115.0) | 50.0 (28.0, 73.0) | < 0.00012 |
| Maximum WBC count (cells/ml) | 15.0 (12.2, 18.7) | 15.8 (11.62, 19.8) | 14.8 (12.1, 19.3) | 13.1 (10.7, 15.2) | 0.022 |
CRP, C-reactive protein; PICC, peripherally inserted central catheter; WBC, white blood cell.
Compare P-values in this subset to Bonferroni-corrected type I error rate α = 0.05/4 = 0.013.
Total number without missing data for these outcomes (denominators): septic emboli (32 cases, 38 controls); PICC (45 cases, 56 controls); readmission or relapse (46 cases, 56 controls); readmission (46 cases, 56 controls); relapse (41 cases, 53 controls).
Compare P-values in this subset to Bonferroni-corrected type I error rate α = 0.05/2 = 0.025.
Compare P-values in this subset to Bonferroni-corrected type I error rate α = 0.05/5 = 0.010.
Compare P-values in this subset to Bonferroni-corrected type I error rate α = 0.05/3 = 0.017.
P-value obtained from the Fisher exact test.
P-value obtained from the Wilcoxon-rank sum test.
P-value obtained from the χ2-test.