Figure 1.

PNN is over-expressed in human prostate cancer. A. PNN is up-regulated in tumor samples. Representative images of immunohistochemical staining with PNN in a cohort of 81 prostate cancer tissues and 22 normal prostate samples. The scale bar = 200 μm (left), 100 μm (right). B. TCGA data analysis of prostate cancer. PNN is over-expressed in tumors, and its over-expression correlates with tumor stage, lymph nodal metastasis, biochemical recurrence and Gleason score. C. The survival analysis based on the TCGA dateset. PNN over-expression indicates poor survival of prostate cancer patients. **P < 0.01, ***P < 0.001.