Figure 6.
PNN over-expression induces prostate cancer cell EMT. A and B. The expression levels of epithelial-to-mesenchymal transition (EMT) related proteins in prostate cancer cells after altering PNN expression. PNN up-regulation triggers tumor cell epithelial-to-mesenchymal transition. C. EMT-related proteins level in xenografts. D. Down-regulation of PNN induced PC-3 cell morphological changes from long, polygonal form to spindle appearances. The scale bar = 200 μm.