Table 2.
Logistic regression for the associated risk factors of LNM in T1N0-3M0 gastric cancer
| Clinicopathological variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
|
|
|
|||
| OR (95% CI) | P | OR (95% CI) | P | |
| Age at diagnosis | ||||
| 18-55 | Reference | Reference | ||
| 56-65 | 0.82 (0.65-1.04) | .100 | 0.78 (0.61-1.01) | .056 |
| 66-75 | 0.84 (0.68-1.05) | .127 | 0.83 (0.66-1.06) | .134 |
| 76+ | 0.59 (0.47-0.73) | < .001 | 0.59 (0.46-0.76) | < .001 |
| Race | ||||
| White | Reference | |||
| Black | 0.94 (0.74-1.19) | .615 | ||
| Others | 0.95 (0.79-1.14) | .592 | ||
| Sex | ||||
| Female | Reference | Reference | ||
| Male | 1.26 (1.08-1.47) | .004 | 1.15 (0.96-1.37) | .127 |
| Grade | ||||
| Well differentiated | Reference | Reference | ||
| Moderately differentiated | 2.90 (2.13-4.05) | < .001 | 2.00 (1.45-2.82) | < .001 |
| Poorly differentiated | 4.74 (3.51-6.55) | < .001 | 2.97 (2.15-4.17) | < .001 |
| Undifferentiated | 3.62 (1.96-6.46) | < .001 | 2.18 (1.15-4.01) | .014 |
| Histology | ||||
| Adenocarcinoma | Reference | Reference | ||
| Signet ring cell carcinoma | 1.29 (1.05-1.58) | .013 | 0.98 (0.77-1.24) | .865 |
| Others | 1.19 (0.95-1.48) | .115 | 1.26 (0.98-1.61) | .067 |
| Primary site | ||||
| Cardia | Reference | Reference | ||
| Non-cardia | 0.83 (0.71-0.97) | .020 | 0.75 (0.63-0.90) | .002 |
| Tumor size (mm) | ||||
| 1-9 | Reference | Reference | ||
| 10-19 | 4.14 (2.85-6.20) | < .001 | 3.54 (2.42-5.34) | < .001 |
| 20-29 | 6.36 (4.38-9.54) | < .001 | 5.44 (3.72-8.22) | < .001 |
| 30+ | 10.57 (7.43-15.58) | < .001 | 9.79 (6.83-14.54) | < .001 |
| Regional nodes examined | ||||
| ≤12 | Reference | Reference | ||
| >12 | 2.21 (1.90-2.57) | < .001 | 2.11 (1.79-2.48) | < .001 |
| Marital status | ||||
| Married | Reference | Reference | ||
| Others | 0.83 (0.71-0.97) | .017 | 0.96 (0.81-1.13) | .612 |
Abbreviations: LNM, lymph node metastasis; 95% CI, 95% confidence intervals; OR, odd ratio.