Table 3.

Logistic regression for the associated risk factors of DM in T1 gastric cancer

Clinicopathological variables	Univariate analysis		Multivariate analysis
	OR (95% CI)	P	OR (95% CI)	P
Age at diagnosis
18-55	Reference		Reference
56-65	0.69 (0.56-0.86)	.001	0.55 (0.42-0.73)	< .001
66-75	0.48 (0.39-0.59)	< .001	0.43 (0.33-0.57)	< .001
76+	0.36 (0.29-0.45)	< .001	0.23 (0.18-0.30)	< .001
Race
White	Reference		Reference
Black	0.88 (0.69-1.10)	.272	0.83 (0.62-1.10)	.203
Others	0.51 (0.41-0.64)	< .001	0.85 (0.64-1.11)	.234
Sex
Female	Reference		Reference
Male	1.41 (1.20-1.66)	< .001	0.89 (0.73-1.10)	.281
Grade
Well differentiated	Reference		Reference
Moderately differentiated	3.52 (2.38-5.41)	< .001	1.87 (1.21-2.98)	.006
Poorly differentiated	7.16 (4.92-10.88)	< .001	3.75 (2.46-5.93)	< .001
Undifferentiated	6.04 (3.23-11.15)	< .001	2.49 (1.20-5.15)	.014
Histology
Adenocarcinoma	Reference		Reference
Signet ring cell carcinoma	0.76 (0.60-0.95)	.018	0.50 (0.37-0.67)	< .001
Others	0.94 (0.75-1.18)	.613	0.98 (0.72-1.31)	.879
Primary site
Cardia	Reference		Reference
Non-cardia	0.40 (0.34-0.46)	< .001	0.59 (0.48-0.72)	< .001
Tumor size (mm)
1-9	Reference		Reference
10-19	5.73 (2.79-13.85)	< .001	5.26 (2.52-12.86)	< .001
20-29	12.19 (6.05-29.11)	< .001	9.46 (4.59-22.91)	< .001
30+	49.88 (25.52-116.86)	< .001	32.66 (16.37-77.51)	< .001
Regional nodes examined
≤12	Reference		Reference
>12	0.06 (0.04-0.08)	< .001	0.04 (0.03-0.06)	< .001
Marital status
Married	Reference
Others	0.90 (0.77-1.05)	.192
N stage
N0	Reference		Reference
Non-N0 (N1/2/3)	4.37 (3.74-5.12)	< .001	3.10 (2.54-3.78)	< .001

Abbreviations: DM, distant metastasis; 95% CI, 95% confidence intervals; OR, odd ratio.