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. 2021 Apr 15;11(4):1369–1390.

Figure 2.

Figure 2

Overexpression of LHPP inhibits glioblastoma progression in vitro and in vivo. A and B. Cell growth curve of U87MG and U118MG cells after transfected with LHPP plasmids or empty vector, detected by the CCK-8 assay (n=4). C. EdU-labeled proliferating cells in U87MG and U118MG cells after transfected with LHPP plasmids or empty vector (×400). D. Statistical result of the EdU-Positive cells ratio in U87MG and U118MG cells after transfected with LHPP plasmids or empty vector (n=12, 3 transfection batches, each batch with 4 replicates). E. Cell clone formation of U87MG and U118MG cells after transfected with LHPP plasmids or empty vector, colonies were stained by crystal violet. F. Statistical result of the number of colonies in U87MG and U118MG cells after transfected with LHPP plasmids or empty vector (n=3). G. Representative in vivo IVIS Luc fluorescence image of xenografts mice at 14th day. H. Statistical result of photon flux in xenografts mice at 14th day (n=9). I. Kaplan-Meier curves of survival rate of xenografts mice (n=6). The data were expressed as the mean ± SEM (*P<0.05, **P<0.001, ***P<0.0001).