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. 2021 Apr 15;11(4):1391–1409.

Figure 7.

Figure 7

Overexpressing p21 attenuates the LH-induced suppression on tumor growth and lung metastasis of melanoma cells. (A) After 3 weeks incubation with DMSO or 20 μM LH, colonies formed by p21/vector-overexpressing cells were imaged and counted. Scale bar, 1 mm. (B) Tumor volume of p21/vector-overexpressing A375 xenograft tumors in mice under LH (30 mg/kg/day for 25 days) or DMSO treatment was measured. (C) Tumors were excised from the mice after 25 days treatment. (D) Weight of the tumors in (C) was measured. (E) IHC staining for p21 and Ki67 was performed in the xenograft tumors. Scale bar, 100 μm. (F) Tumors in the lung of mice that metastasized with p21/vector-overexpressed A375 cells were observed after LH (30 mg/kg/day for 40 days) or DMSO treatment. H&E; Scale bar, 1 mm. Mean ± SD; *P<0.05, **P<0.01, ***P<0.001.