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. 2021 Apr 15;11(4):1347–1368.

Figure 3.

Figure 3

The migration, invasion and proliferation of PRAD cells line were investigated, BLM inhibitors reduce PC3 cells growth and found that treatment with ML216 had affected on PC3 cell cycle. A-C. The migration, invasion and proliferation ability of RWPE-1, PC3, 22RV-1 and LNcap cells was detected. Columns, mean of three independent experiments; bars, SD (n=3). *, P<0.05. D. The expressions of BLM, EZH2 and P53 in PRAD cells line were detected by Western blot, GAPDH is used as a loading control. E. ML216 treatment (5 days) inhibits PC3 cell proliferation, ***P<0.001, one-way ANOVA, n=3. F. ML216 treatment (5 days) induced PC3 cells have G0/G1 phase arrest. Cells were stained with PI and analyzed by flow cytometry. Date represented one of two independent experiments.