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. 2021 Apr 15;11(4):1697–1708.

Figure 4.

Figure 4

Efficacy of CAN017 prospectively guided by NRG1 expression in cohort 2. A. Tumor growth curves showed the in vivo activity of 5 ESCC PDX models treated with vehicle control and CAN017 (20 mg/kg). Data were expressed as means ± SDs for at less five mice in each group. The anti-tumor activity was depicted by TGI as described in each picture. B. NRG1 mRNA expression levels of 5 ESCC tumors and the efficacy of CAN017 on PDX models. Blue dotted lines showed the threshold of NRG1 ΔCt and the TGI of 70%, respectively.