Table 3.
Sensitivity of IGF2BP3-overexpressing HCT8 cells to cytotoxic agents in comparison with that of control HCT8 cells
| Compounds | IC50 (mean ± SD) (μM) | RF | |
|---|---|---|---|
|
| |||
| HCT8+Vector | HCT8+IGF2BP3 | ||
| DOX | 0.2008±0.0087 | 0.3987±0.0195*** | 1.98 |
| PTX | 0.0268±0.0011 | 0.0446±0.0031** | 1.66 |
| VCR | 0.1542±0.0264 | 0.3381±0.0161** | 2.19 |
| NVB | 0.0289±0.0031 | 0.0918±0.0077*** | 3.17 |
| TPT | 0.0859±0.0028 | 0.0549±0.0025 | 0.64 |
| OXA | 1.3482±0.0094 | 1.3562±0.0341 | 1.01 |
The experiments were conducted as described in Materials and methods. The reversal-fold (RF) was calculated by dividing the IC50 values of agents for HCT8+IGF2BP3 cells by that for HCT8+Vector cells. Data are shown as mean ± SD (n = 3).
**
P < 0.01 (Student’s t-test);
***
P < 0.001 (Student’s t-test).