Table 4.
Sensitivity of IGF2BP3-knockdown HCT8/T cells to cytotoxic agents in comparison with that of the control HCT8/T cells
| Compounds | IC50 (mean ± SD) (μM) | RF | |
|---|---|---|---|
|
| |||
| HCT8/T shNC | HCT8/T shIGF2BP3-1 | ||
| DOX | 2.7807±0.2405 | 2.1127±0.0805* | 0.76 |
| PTX | 2.2103±0.1309 | 1.6718±0.0715** | 0.76 |
| VCR | 2.0528±0.1326 | 0.7846±0.0986*** | 0.38 |
| NVB | 0.7798±0.0663 | 0.3624±0.0240*** | 0.46 |
| TPT | 0.0174±0.0023 | 0.0155±0.0020 | 0.89 |
| OXA | 0.7644±0.0578 | 0.7462±0.0221 | 0.98 |
The experiments were conducted as described in Materials and methods. The reversal-fold (RF) was calculated by dividing the IC50 values of agents for HCT8/T shIGF2BP3-1 cells by that for HCT8/T shNC cells. Data are shown as mean ± SD (n = 3).
*
P < 0.05 (Student’s t-test);
**
P < 0.01 (Student’s t-test);
***
P < 0.001 (Student’s t-test).