Table 6.
Loss of IGF2BP3 enhanced the response of HCT8/T xenografts to NVB and PTX
| Cell lines | Group | Schedule | Body weight (g) | Tumor volume (mm3) | Tumor weight (g) | RTV | T/C | TGI (%) | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||
| D16 | D36 | D16 | D36 | |||||||
| HCT8/T shNC | Vehicle | / | 17.87±0.20 | 18.44±0.43 | 75.42±8.31 | 1235.14±182.40 | 0.76±0.11 | 16.72±2.00 | / | / |
| NVB | 4 mg/kg; q3d; iP | 17.40±0.53 | 16.60±0.71 | 75.80±8.34 | 1259.77±100.69 | 0.72±0.09 | 17.65±1.65 | 1.06 | -2.18 | |
| PTX | 20 mg/kg; q3d; ip | 18.03±0.36 | 17.43±0.66 | 74.54±8.36 | 1050.67±16.01 | 0.58±0.29 | 14.17±1.61 | 0.85 | 15.83 | |
| HCT8/T shIGF2BP3 | Vehicle | / | 17.53±0.20 | 17.96±0.28 | 92.11±8.31 | 2476.17±272.92 | 1.66±0.16 | 28.37±4.00 | / | / |
| NVB | 4 mg/kg; q3d; iP | 18.09±0.44 | 17.74±0.35 | 91.46±7.92 | 1377.19±247.76 | 1.02±0.18* | 14.66±2.43* | 0.52 | 46.07 | |
| PTX | 20 mg/kg; q3d; ip | 18.17±0.44 | 17.30±0.35 | 90.77±6.78 | 1120.31±108.87 | 0.93±0.06** | 12.96±1.49** | 0.46 | 56.82 | |
Changes in body weight, tumor volume, tumor weight and relative tumor volume (RTV) after HCT8/T shNC and shIGF2BP3 cells inoculation. The experiments were conducted as described in Materials and methods. Data are presented as mean ± SEM (n = 7) for each group.
*
P < 0.05 (Student’s t-test);
**
P < 0.01 (Student’s t-test).