Figure 1.

The angiogenesis score was associated with expressions of angiogenesis-related genes. Boxplots showing comparisons of the expression levels of (A) vascular endothelial growth factor (VEGF)-related genes, (B) endothelial cell marker-related genes; and (C) vascular stability-related genes, between low and high angiogenesis score groups in the TCGA and GSE84437 cohorts. We defined the VEGF-related genes as VEGFA, VEGFB, VEGFC, VEGFR1 (FLT1), VEGFR2 (KDR), VEGFR3 (FLT4), and PGF, and the endothelial cell marker-related genes as VWF, CD31 (PECAM1), and CD34, and vascular stability-related genes as ANGPT1, ANGPT2, TIE1, TIE2 (TEK), VE-cadherin (CDH5), JAM2 and Claudin5 (CLDN5).