The angiogenesis score was associated with clinical cancer aggressiveness. Boxplots of the angiogenesis score by (A) AJCC stage, T- and N-category in the TCGA, GSE26901, and GSE84437 cohorts. (B) Kaplan-Meier curves of OS in the TCGA (n = 368) and GSE84437 (n = 432) cohorts, and DFS in the GSE26253 (n = 432) cohort of angiogenesis score high (red) and low (blue) in gastric cancer. AJCC, American Joint Committee on Cancer; disease-free survival, DFS; overall survival, OS.