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The structure of the Androgen Receptor showing binding sites of inhibitors and activators of AR signalling. The ligand for AR, DHT binds to the Activation Region 2 located in the LBD. Abiraterone can prevent this binding. The Activation region 1 is the location of protein-protein interactions and allows AR to bind to cofactors which is essential for its activity. The small molecule EPI-001 can prevent this.
