TABLE 1.
Study population demographic characteristics
| Total (n = 39) | Good responders (n = 20) b | Poor responders (n = 19) b | p value | |
|---|---|---|---|---|
| Age at diagnosis, years | ||||
| Mean age at diagnosis (range) [CI] | 59.4 (39−82) [56.3−62.5] | 59.2 [54.0−64.4] | 59.7 [55.8−63.5] | 0.88 |
| Stage | ||||
| 3 | 36 | 20 | 16 | 0.11 |
| 4 | 3 | 0 | 3 | |
| Ca125 | ||||
| Value at diagnosis (mean) | 2254 | 1526 | 2982 | 0.04 |
| Value at diagnosis (median) | 1085 | 599 | 1678 | |
| BRCA germline status a | ||||
| Positive (Carrier) | 5 | 4 | 1 | 0.18 |
| Negative (WT) | 31 | 14 | 17 | |
| Unknown | 3 | 2 | 1 | |
| Residual disease | ||||
| Mean (in cm) [CI] | 5.4 [4.3−6.4] | 4.4 [3.1−5.8] | 6.4 [4.7−8.1] | 0.069 |
| Vascular invasion | ||||
| Positive | 18 | 11 | 7 | 0.73 |
| Negative | 16 | 8 | 8 | |
| Not documented | 5 | 1 | 4 | |
| Total lines of chemotherapy | ||||
| Mean [CI] | 2.8 [2.3−3.3] | 2.4 [1.6−3.1] | 3.2 [2.6−3.8] | 0.09 |
| Progression‐free interval | ||||
| Median (months) | 10 | 32 | 3 | <0.001 |
| gBRCA+ | 11 | 50.5 (4) | 0 (1) | |
| gBRCA− | 6 | 32.5 (14) | 4 (17) | |
| Unknown | 17 | 25.5 (2) | 3 (1) | |
| Overall survival | ||||
| Median (months) | 41 | 65.5 | 23 | <0.001 |
| gBRCA+ | 60 | 76.5 (4) | 37(1) | |
| gBRCA− | 41 | 71.5 (14) | 23 (17) | |
| Unknown | 29 | 33.5 (2) | 16 (1) | |
Abbreviations: CI, 95% confidence interval; WT, wild‐type.
a
BRCA1 and BRCA2 germline mutation status as assessed by local testing.
b
Sample size shown within parentheses.