Fig. 1.

Metabolite pathway analysis. Pathways of glycolysis, pentose phosphate, tricarboxylic acid (TCA), purine, and lipid metabolism are shown as bar graphs: light green [H_SD], SD heart; green [H_ZK], ZDF heart; light purple [K_SD], SD kidney; purple [K_ZK], ZDF kidney; light blue [L_SD], SD liver; and dark blue [L_ZK], ZDF liver. Opposite behaviors between the precursor and product (e.g., nicotinamide to 1-methylnicotinamide or adenine to hypoxanthine in the heart) are highlighted with magnified bar graphs. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)