Fig. 2.

TADs and loops visualization with annotation. From top to bottom, the following visualization is shown: RNA-seq, Dnasel, CTCF (Broad), H3K27ac annotation and Hi-C contact heatmap. For the Hi-C contact heatmap, Squares of contact frequency along with the diagonal (yellow squares) indicate the TADs, peaks (black points) in the contact heatmap indicate the chromatin loops. (Note: this Figure is drawn using the juicer box tool [87], Data Source: Rao and Huntley et al. [18] Cell GM12878 Hi-C in situ chr1: 63,820,000–72,460,000). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)