Fig. 3.

Process of simulating chromosomes’ 3D structure. First, data is preprocessed to get distance matrix or contact data, which is used as the second step’s input. Second, we could choose or not choose some prior conditions (such as biological characteristics, physical forces, and FISH data) to help us build chromosome reconstruction models. In the past ten years, most researchers chose to reconstruct chromosomes by probability-based inferential, distance-based or contact-based methods. At the end of the analysis, we will have a 3D coordinate set for visualization.