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IL-5 expression is required for IL-33–mediated survival of S. aureus–induced pneumonia. Shown is a Kaplan-Meier survival curve for IL-5+/− or IL-5−/− mice. Mice were treated i.t. with PBS or IL-33 for 3 days, which was followed by i.t. infection with S. aureus on Day 0. All groups were monitored for survival for 7 days. Statistical significance was determined using a log-rank (Mantel-Cox) test. The graph is pooled from two experiments (n = 5–9 mice per group). *P < 0.05.
