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. 2021 Apr 29;13:98. doi: 10.1186/s13148-021-01083-9

Table 4.

Table of example for the transformation of Beta-Values to M-values and the differences, respectively. The Beta-value difference between the Placebo group and the Treatments group is constant at 10%. Due to the transformation, the M-values differ and the differences in M-values can not be mapped to the differences in Beta-values

GrpPlacebo GrpTreatment ΔBeta ΔM Regression formula
Beta-value M-value Beta-value M-value on M-values
0.001 -9.96 0.101 -3.15 0.10 6.81 -9.96 + 6.81 · GrpTreatment
0.101 -3.15 0.201 -1.99 0.10 1.16 -3.15 + 1.16 · GrpTreatment
0.201 -1.99 0.301 -1.22 0.10 0.77 -1.99 + 0.77 · GrpTreatment
0.301 -1.22 0.401 -0.58 0.10 0.64 -1.22 + 0.64 · GrpTreatment
0.401 -0.58 0.501 0.01 0.10 0.59 -0.58 + 0.59 · GrpTreatment
0.501 0.01 0.601 0.59 0.10 0.58 0.01 + 0.58 · GrpTreatment
0.601 0.59 0.701 1.23 0.10 0.64 0.59 + 0.64 · GrpTreatment
0.701 1.23 0.801 2.01 0.10 0.78 1.23 + 0.78 · GrpTreatment
0.801 2.01 0.901 3.19 0.10 1.18 2.01 + 1.18 · GrpTreatment
0.901 3.19 0.999 9.96 0.10 6.77 3.19 + 6.77 · GrpTreatment