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. 2021 Mar 25;48:101220. doi: 10.1016/j.molmet.2021.101220

Figure 2.

Figure 2

Unaltered energy balance in macrophage-specific Adrb2 knockout mice. (A) Growth curves of Adrb2fl/fl (n = 8) and Adrb2fl/flLyz2Cre/+ (n = 8) male mice on a chow-diet. (B) Weights of Adrb2fl/fl (n = 19) and Adrb2fl/flLyz2Cre/+ (n = 17) chow-fed male mice at one year of age. (C) Energy expenditure of Adrb2fl/fl (n = 8) and Adrb2fl/flLyz2Cre/+ (n = 8) chow-fed 4-month-old male mice. (D) Body weights and (E) cumulative chow intake of Adrb2fl/fl (n = 8) and Adrb2fl/flLyz2Cre/+ (n = 8) mice, measured over 11-day period, and (F) cumulative fecal weight, measured over days 7–11 of the experiment. Growth curves of (G) the first cohort of Adrb2fl/fl (n = 8) and Adrb2fl/flLyz2Cre/+ (n = 8) and the second cohort of Adrb2fl/fl (n = 10) and Adrb2fl/flLyz2Cre/+ (n = 11) male mice on HFD. (I) Energy expenditure of the first cohort of Adrb2fl/fl (n = 7) and Adrb2fl/flLyz2Cre/+ (n = 7) 4-month-old male mice after 9 weeks of HFD. (J) Body weights and (K) cumulative HFD intake of Adrb2fl/fl (n = 8) and Adrb2fl/flLyz2Cre/+ (n = 8) mice, measured over the first 11 days after the change to HFD, and (L) cumulative fecal weight, measured over days 7–11 of the experiment. All graphs show means ± SEM.