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. 2021 Mar 23;3(1):vdab046. doi: 10.1093/noajnl/vdab046

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© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Functional domains and G protein coupling of aGPCRs implicated in GBM. The schematic shows structures and functional domains at the NTF of GPR124, BAI1, GPR133, CD97, GPR56, CELSR1, and ELTD1. G protein coupling is indicated by arrows. To date, G protein coupling of GPR124 and ELTD1 has not been documented. GAIN, GPCR autoproteolysis-inducing domain; GPS, GPCR proteolysis site; HBD, hormone-binding domain; Ig, immunoglobulin domain; LRRCT, leucine-rich repeat C-terminal domain; LRR, leucine-rich repeat; RGD, Arg-Gly-Asp motif; TSR, thrombospondin type 1 repeat; PRR, proline-rich region; laminin_G/PTX, laminin_G/pentraxin; EGF, epidermal growth factor domain; PLL, pentraxin/laminin/neurexin/sex-hormone-binding-globulin-like domain.