Table 5.
Maximum number of evidence elements attainable by variant type using the CanVIG-UK specification
| Variant type | Maximum number of pieces of evidence at each strength | ||||||
| Pathogenicity | Benignity | ||||||
| Very strong | Strong | Moderate | Supporting | Supporting | Strong | Standalone | |
| Truncating | 4 | 7 | 8 | 9 | 4 | 5 | 1 |
| Missense | 3 | 7 | 9 | 12 | 6 | 5 | 1 |
| In-frame indel | 3 | 6 | 9 | 10 | 5 | 5 | 1 |
| Synonymous | 3 | 6 | 7 | 9 | 6 | 5 | 1 |
PP5 and BP6 (reputable source) are permitted by the CanVIG-UK specification 2020 at supporting level and so are included in the totals above, despite not being permitted by Brnich et al 19
CanVIG-UK, Cancer Variant Interpretation Group UK.