Table 7.

Examples of potential combinations of conflicting evidence and the resultant CanVIG-UK classification that would be given

Evidence elements for pathogenicity	Evidence elements for benignity	Net exponent score	CanVIG-UK assignation of variant class
Towards pathogenicity: 8 (very strong), 4 (strong), 2 (moderate), 1 (supporting); towards benignity: −4 (strong), −1 (supporting)
8+4	(−1)	11	Likely pathogenic
8+4	(−1)+(−1)	10	VUS
8+4	(−4)	8	VUS
4+4	(−1)	7	Likely pathogenic
4+4+1	(−1)+(−1)	7	VUS
1	(−4)	-3	Likely benign
1+1	(−4)+(−4)	-6	VUS

CanVIG-UK, Cancer Variant Interpretation Group UK; VUS, Variant of Uncertain Significance.