Fig. 4.

ZBTB28 suppressed tumorigenicity in vivo. a Representative pictures showing tumor growth 18 days after subcutaneously implanted cervical cancer cells. b Tumors’ volume was measured on day 4, 8, 10, 12, 14, 16, 18. c The weight of vector-group and ZBTB28-group tumors were measured respectively (n = 5). d Representative images of HE staining, PCNA expression. Apoptosis was assessed by TUNEL assays in xenografts. e HeLa cells were intravenously injected into BALB/c mice to induce lung metastasis. Lung metastatic loci were counted on day 15. All statistical data were shown as mean ± SEM. *p < 0. 05