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Novel environment stress for 60 min induces a rapid defecatory peak response in the first 15 min (A), increased urine spots (B), and decreased ambulatory response (C), as monitored concomitantly in female CRF-OE mice compared with their WT littermates. Each bar or point represents the mean ± SE of the number of mice indicated at the bottom of columns or in parentheses. *P < 0.05 vs. all other time points (repeated one-way ANOVA); #P < 0.05 vs. WT littermates (t-test).
