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. 2021 Apr 30;14:75. doi: 10.1186/s13041-021-00783-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Ontological Analysis of the Proteome Sensitive to Activity Deprivation and Fmr1^−/y. a Synaptic Ontology Analysis using the SYNGO tool. Sunburst plots represent synaptic annotated GO BP ontologies. Colors represent -log10 FDR corrected p values. Gene sets are defined in Fig. 1. SFARI correspond to the autism spectrum disorder genes curated by https://gene.sfari.org/database/human-gene/. HP-0000729 corresponds to the Human Phenotype Ontology annotated term Autistic behavior HP:0000729 (https://hpo.jax.org/app/browse/term/HP:0000729). b GO CC Term ontology analysis performed with the ENRICHR tool. All proteins sensitive to TTX-APV plus those sensitive to the Fmr1^−/y genotype (red bars) were compared to wild type TTX-APV treated hits (black bars) and Fmr1^−/y TTX-APV treated hits (green bars). c ClueGO Ontology Analysis of all TMT Hits defined by the red bar in B. Node size represents number of mapped genes. d ClueGO Ontology gene percentage contributions among the three gene sets in b. e ClueGO Ontology Statistics. Non-corrected Two Sided Hypergeometric Test. See Additional file 2: Table S2