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. 2021 Apr 30;14:75. doi: 10.1186/s13041-021-00783-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The mitoproteome sensitive to activity deprivation and Fmr1^−/y. a Venn diagram comparing all Mitocarta 2.0 entries with all TMT quantified proteins (6074), all hits sensitive to TTX-APV plus those sensitive to the Fmr1^−/y genotype (335). b Venn diagram comparing all Mitocarta 2.0 mitoproteome with protein hits sensitive to TTX-APV in wild type cells (159) or Fmr1^−/y cells (260) and all TMT proteome hits (335). c Hierarchical clustering analysis of the expression of 34 proteins in wild type and Fmr1^−/y cells treated with vehicle or TTX-APV. Kendal Tau clustering analysis of rows. d Venn diagram comparing the 34 mitochondrial proteins listed in c and those puromycinylated after NMDA treatment of synaptosomes [39]. e Normalized TMT Log2 expression of top mitochondrial hits. Kruskal–Wallis Test followed by Mann–Whitney U Test. n = 6 wild type and n = 4 Fmr1^−/y for vehicle treated cultures, n = 5 for each genotype treated with TTX-APV TTX-APV-treated. f Interactome of the TTX-APV and Fmr1^−/y sensitive mitoproteomes. Blue nodes represent upregulated proteins. Grey represent downregulated proteins. g Venn diagram of all TMT hits, the Mitocarta 2.0 dataset and two autism spectrum disorder curated gene sets. h Venn diagram of Mitocarta 2.0 dataset and the Suhl et al. curated Fmrp targets