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. 2021 Apr 30;40:148. doi: 10.1186/s13046-021-01943-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — BBOX1-AS1 is up-regulated and predicts an inferior prognosis in NSCLC. a and b Heatmap of differentially expressed lncRNAs in lung cancer based on microarray datasets (GSE18842 and GSE19188). c Venn diagram displaying seven up-regulated lncRNA in NSCLC in both GSE18842 and GSE19188. d Expression of BBOX1-AS1 in LUAD and LUSC based on starBase Pan-Cancer Analysis Platform. e The correlation between BBOX1-AS1 expression and prognosis of NSCLC patients was evaculated by the Kaplan-Meier plotter database. f qRT-PCR analysis of BBOX1-AS1 expression in tumor tissues and corresponding non-cancerous tissues from a cohort of 76 ESCC patients. g Kaplan-Meier survival curve was used to examine the overall survival of NSCLC patients with high/low expression of BBOX1-AS1. h BBOX1-AS1 expression was measured by qRT-PCR in bronchial epithelial cell line BEAS-2B and four NSCLC cells. **P < 0.01, ***P < 0.001