Table 3.
Association of Maternal-Reported Internalizing Symptoms With Timing of Subsequent Development of Pubertal Characteristicsa in Girls Aged < 8 Years and Prepubertal at Recruitment in the Lessons in Epidemiology and Genetics of Adult Cancer From Youth Girls Study (n = 1,040), 2011–2016
| Symptom in Girls | Breast Development b | Pubic Hair Development c | ||||
|---|---|---|---|---|---|---|
| HR d | 95% CI | P Value | HR d | 95% CI | P Value | |
| Anxietye | 1.40 | 1.11, 1.76 | 0.01 | 1.23 | 0.94, 1.61 | 0.13 |
| Depressione | 1.28 | 1.03, 1.58 | 0.02 | 1.09 | 0.86, 1.40 | 0.47 |
| Somatizatione | 1.23 | 0.98, 1.53 | 0.07 | 1.08 | 0.82, 1.42 | 0.58 |
| Internalizinge | 1.37 | 1.10, 1.72 | 0.01 | 1.16 | 0.89, 1.51 | 0.27 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
a Menarche could not be evaluated because few girls younger than 8 years reached menarche.
b n = 181; no. of events = 93; cumulative days of follow-up = 160,913.
c n = 183; no. of events = 64; cumulative days of follow-up = 179,762.
d HR is for a 1–standard deviation change in the psychosocial factor adjusted for age at assessment, race/ethnicity, study center, maternal education, body mass index percentile, breast cancer family history.
e Anxiety, depression, and somatization data from the parent-reported internalizing subscales of the Behavior Assessment System for Children-2 (percentiles). Internalizing is a composite of the other scales.