Fig. 3.

The ExCEL signals described in Eq. (3) use decorrelation gates to exclude intravascular flow and highlight diffusion-driven extravascular leakage. A) ExCEL signals with later decorrelation gates visualize slower diffusion. B) A false color leakage map can be generated by overlaying the traditional angiogram signal (red) with the ExCEL₁ (green) and ExCEL₂ (blue) signals. C) ExCEL components with different decorrelation gates are shown individually. A bloom of leakage signal is visible above the retinal lesion marked with a red arrow. This region can be seen in more detail in Fig. S2. Images are shown as mean intensity projections over 40 µm laterally or 20 µm axially as marked by the dashed lines in the enface and B-scan images. These images are shown at the same location as Fig. 2(C). ExCEL images are all shown with the same dynamic range and scale bars are 100 µm. Yellow and magenta boxes mark ROIs containing strong leakage and vascular signals which are further analyzed in Fig. 5 and Fig. 6 respectively.