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. 2021 Mar 23;12(4):2280–2298. doi: 10.1364/BOE.415962

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Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.

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Fig. 2. — (A) is a histopathologically stained H&E image, (B) shows the image pre-processing of a histopathologically stained H&E image including image registration and patch extraction of size 256 $\times$ 256, (C) is a corresponding NLM image, (D) visualizes the contrast inversion of the NLM image followed by patch extraction of size 256 $\times$ 256, (E) shows a CGAN model for paired image translation which utilizes the registered histopathologically stained H&E images and contrast inverted NLM images, (F) depicts a cycle CGAN model for unpaired image translation using unregistered histopathologically stained H&E images and contrast inverted NLM images.