Table 1.

Parameters before left anterior descendent artery (LAD) occlusion; parameters 15, 30 and 45 min after LAD occlusion and 15 min after reperfusion.

Effects of coronary occlusion on hemodynamic parameters
Hemodynamic parameters (n = 18)	LAD occlusion				LAD reperfusion + DB/NA
	Basal	LAD 15 min	LAD 30 min + DB/NA	LAD 45 min + DB/NA
SAP [mmHg]	95.1 ± 14.4	87.2 ± 14.2*	95.3 ± 24.3	101.2 ± 12.5	105.2 ± 12.3*
MAP [mmHg]	73.6 ± 10.2	68.1 ± 12.5	74.7 ± 20.4	78.3 ± 12.5	71.2 ± 11.4
CO [l/min]	5.2 ± 1.1	4.6 ± 1.3*	5.0 ± 1.2	5.6 ± 1.1	6.10± 1.4*
SV [mL]	59.9 ± 12.0	51.6 ± 15.5**	50.9 ± 14.0**	56.3 ± 12.8	51.4 ± 11.6**
HR [bpm]	88.1 ± 17.5	90.3 ± 13.6	98.8 ± 13.0*	99.9 ± 12.5*	116.4 ± 16.5**
PCWP [mmHg]	16.0 ± 3.0	18.8 ± 3.0**	21.1 ± 3.9**	20.9 ± 3.0**	23.4 ± 3.8**
MPAP [mmHg]	23.7 ± 5.2	24.4 ± 5.7	25.7 ± 6.6	27.9 ± 6.0**	31.4 ± 6.5**
CVP [mmHg]	9.9 ± 2.9	11.4 ± 2.8*	12.6 ± 3.1**	13.5 ± 3.0**	13.7 ± 3.2**
SVO2 [%]	69.4 ± 12.6	65.0 ± 7.0	72.3 ± 8.9	77.7 ± 6.8*	76.9 ± 7.4*

Values are expressed as mean ± standard deviation. LAD occlusion led to a significant decline in MAP, CO and SV in the first 15 min after LAD occlusion. Dobutamine and noradrenaline, along with fluids, were administered after 15 min of occlusion to preserve adequate hemodynamics during induction of myocardial infarction.

^*p < 0.05;

^**p < 0.01. N = 18 (all animals, both groups);

DB — dobutamine; NA — noradrenaline; SAP — systolic arterial pressure; MAP — mean arterial pressure; CO — cardiac output; SV — stroke volume; HR — heart rate; PCWP — pulmonary capillary wedge pressure; MPAP — mean pulmonary artery pressure; CVP — central venous pressure; SVO₂ — mixed venous oxygen saturation