Table 2.
Hemodynamic values after myocardial infarction and reperfusion in ivabradine (n = 9) and control (n = 9) groups. Hemodynamic parameters were measured before randomization and 15, 30, 45 and 60 min after drug (ivabradine or placebo) administration.
| Variable | Group | Effects of ivabradine on hemodynamic parameters. Hemodynamic values | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Before randomization | 15 min after drug administration | 30 min after drug administration | 45 min after drug administration | 60 min after drug administration | ||
| HR [bpm] | Control | 119.6 ± 10.0 | 122.7 ± 17.3 | 123.2 ± 19.4 | 124.0 ± 22.2 | 121.4 ± 26.6 |
| Ivabradine | 113.2 ± 21.3 | 88.4 ± 12.0** | 88.0 ± 12.6** | 86.6 ± 13.3** | 88.1 ± 14.8** | |
| MAP [mmHg] | Control | 70.7 ± 12.1 | 68.7 ± 10.7 | 73.7 ± 8.1 | 70.4 ± 10.0 | 71.2 ± 11.6 |
| Ivabradine | 71.8 ± 11.2 | 66.1 ± 10.1 | 70.0 ± 13.3 | 72.3 ± 15.6 | 65.0 ± 13.3 | |
| SV [mL] | Control | 46.2 ± 12.8 | 52.4 ± 11.5 | 54.2 ± 13.2 | 53.5 ± 12.3 | 54.5 ± 11.4 |
| Ivabradine | 56.7 ± 7.6 | 68.8 ± 13.7* | 62.1 ± 7.5 | 60.8 ± 7.9 | 59.1 ± 8.5 | |
| CO [l/min] | Control | 5.5 ± 1.5 | 6.5± 1.9 | 6.7 ± 2.0 | 6.7 ± 2.1 | 6.9 ± 2.2 |
| Ivabradine | 6.4 ± 1.3 | 6.1 ± 1.4 | 5.5 ± 1.2 | 5.3 ± 1.3 | 5.3 ± 1.5 | |
| PCWP [mmHg] | Control | 22.7 ± 3.4 | 19.7 ± 2.7 | 19.0 ± 2.5 | 17.8 ± 2.3 | 17.2± 1.7 |
| Ivabradine | 24.2 ± 4.2 | 21.3 ± 5.1 | 20.2 ± 2.9 | 19.4 ± 3.6 | 19.8 ± 3.1 | |
| MPAP [mmHg] | Control | 31.8 ± 6.0 | 30.1 ± 6.2 | 29.0 ± 5.5 | 27.4 ± 6.2 | 28.1 ± 6.4 |
| Ivabradine | 31.1 ± 7.4 | 30.3 ± 7.9 | 29.3 ± 7.5 | 27.9 ± 5.9 | 27.7 ± 5.3 | |
| CVP [mmHg] | Control | 14.1 ± 3.2 | 11.3 ± 3.3 | 10.8 ± 3.4 | 10.4 ± 3.9 | 9.9 ± 3.1 |
| Ivabradine | 13.3 ± 3.5 | 13.9 ± 3.2 | 13.4 ± 2.8 | 13.4 ± 2.2* | 12.8 ± 2.9 | |
| SVO2 [%] | Control | 76.4 ± 5.9 | 76.3 ± 10.9 | 77.0 ± 12.7 | 74.0 ± 13.1 | 78.1 ± 8.2 |
| Ivabradine | 77.3 ± 9.0 | 75.6 ± 8.7 | 74.4 ± 8.9 | 74.8 ± 9.4 | 75.3 ± 7.8 | |
Values are expressed as mean ± standard deviation.
*
p < 0.05 for effect of ivabradine vs. control on hemodynamic parameters;
**
p< 0.01 for effect of ivabradine vs. control on hemodynamic parameters;
HR — heart rate; MAP — mean arterial pressure; SV — stroke volume; CO — cardiac output; PCWP — pulmonary capillary wedge pressure; MPAP — mean pulmonary artery pressure; CVP — central venous pressure; SVO2 — mixed venous oxygen saturation