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. 2021 Apr 16;12:642549. doi: 10.3389/fmicb.2021.642549

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Copyright © 2021 Rodríguez-Sorrento, Castillejos, López-Colom, Cifuentes-Orjuela, Rodríguez-Palmero, Moreno-Muñoz, Luise, Trevisi and Martín-Orúe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolution of average fecal scores for the different experimental groups during the post-inoculation (PI) period. CTR+: non-inoculated animals receiving placebo; PRO−: inoculated animals receiving the probiotics; PRE−: inoculated animals receiving the prebiotic; SYN−: inoculated animals receiving the synbiotic; CTR−: inoculated animals receiving placebo. N = 6 for all groups except for non-challenged animals (N = 8). MUC4 represents the effect of polymorphism of the MUC4 gene. a,b, and c indicate statistically significant differences between groups. x and y indicate statistical trends among groups. Bars correspond to the standard error. PI, post-inoculation.