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. 2021 Apr 16;12:642549. doi: 10.3389/fmicb.2021.642549

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Copyright © 2021 Rodríguez-Sorrento, Castillejos, López-Colom, Cifuentes-Orjuela, Rodríguez-Palmero, Moreno-Muñoz, Luise, Trevisi and Martín-Orúe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactions between MUC4 gene polymorphism and diets on pH values, total short-chain fatty acids (SCFA), valerate molar ratio, and branched-chain fatty acids molar ratio (BCFA) on day 8 PI. CTR+: non-inoculated animals receiving placebo; PRO−: inoculated animals receiving the probiotics; PRE−: inoculated animals receiving the prebiotic; SYN−: inoculated animals receiving the synbiotic; CTR−: inoculated animals receiving placebo. N = 6 for all groups except for non-challenged animals (N = 8). MUC4 represents the effect of polymorphism of the MUC4 gene. a and b indicate statistically significant differences between groups. Bars correspond to standard error. BCFA, branched-chain fatty acids; MUC4+, Mucin 4 susceptible genotype; MUC4−, Mucin 4 resistant genotype; SCFA, short-chain fatty acids.