. 2021 Apr 16;12:642549. doi: 10.3389/fmicb.2021.642549

Table 6.

Effect of experimental treatments in serum levels of acute-phase protein Pig-MAP and TNF-α.

	Treatment					RSD	p
	CTR +	PRO	PRE	SYN	CTR−	RSD	p
TNF-α (pg/ml)
Day 4 PI	85.7^ab	97.6^ab	75.3^b	118.2^a	76.7^b	23.83	0.023^*
Day 8 PI	83.6	74.3	83.1	70.2	93.8	13.68	0.050
Pig-MAP (mg/ml)
Day 4 PI	0.59^b	0.76^b	0.72^b	1.49^ab	2.42^a	0.986	0.013^*
Day 8 PI	0.51^b	0.57^b	0.56^b	2.43^a	0.62^b	0.752	0.003^*

CTR+: non-inoculated animals receiving placebo; PRO: inoculated animals receiving the probiotics; PRE: inoculated animals receiving the prebiotic; SYN: inoculated animals receiving the synbiotic; CTR−: inoculated animals receiving placebo. N = 6 for all groups except for non-challenged animals (N = 8). Values of p were obtained by an ANOVA using the generalized linear procedure in R software. ^a,bIndicate statistically significant differences between groups. TNF-α, tumor necrosis factor alpha; Pig-MAP, pig major acute-phase protein; PI, post-inoculation; RSD, relative standard deviation. To differentiate RSD and values of p from the results numbers, they are in italics. *indicates that values of p are <0.05 and statistical difference is present.