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. 2021 Apr 16;9:640753. doi: 10.3389/fcell.2021.640753

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Copyright © 2021 Zhi, Zhou, Yu, Yuan, Zhang, Ng, Xu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WDR62 in spermatogenesis. (A) Male meiosis begins with a cell called a primary spermatocyte. Spermatids are the products of meiosis from the tetraploid primary spermatocytes via meiotic cell division. (B) WDR62 deficiency resulted in a loss of germ cells at P3, P5 and P10, which was gradually recovered from at P14-P21. During meiosis, the spindle of spermatocytes from Wdr62 KO mice is disrupted, and the position of the spindle poles is asymmetric. The intensity of α-tubulin is markedly diminished in WDR62 deficient spermatocytes, and the angle of intersection between the polar axis of the main axis and the plane direction (θ) is markedly increased, leading to meiotic arrest. P, postnatal day.