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. 2021 Apr 28;13(4):evab076. doi: 10.1093/gbe/evab076

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — (a) The list of KEGG (the database of manually drawn pathway maps) pathways (b) human phenotypes (HPO) enriched for promoters regulated by regions with highly differentiated variants between wolves and dogs. FDR threshold of 0.01 is used and only the first 30 terms are shown. The size of the blue dots is proportional to the FDR value. The tree is constructed using the distance between two gene sets based on the number of genes in the intersection and the union of two sets. The distance matrix is then used to construct a hierarchical clustering tree based on the number of shared and unique genes between the different sets.