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. 2021 Apr 16;9:649830. doi: 10.3389/fcell.2021.649830

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Copyright © 2021 Landin Malt, Clancy, Hwang, Liu, Smith, Smith, Hatley, Clemens and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rac1 activation and Gsk3β inactivation recovered Fzd6 junctional localization but not planar asymmetry in Wls-deficient OC. (A–L) Flat-mounted E18.5 wild-type control (A,B), Rac1DA/+ (C,D), Gsk3β^cKO (E,F), Wls^cKO (G,H), Wls^cKO; Rac1DA/+ (I,J), and Wls^cKO; Gsk3β^cKO (K,L) OC stained for Fzd6 and ZO-1 as indicated. Arrows indicate Fzd6 crescents along the medial borders of OHCs. Arrowheads indicate the inner pillar cell row. Lateral is up. Scale bar: 6 μm. (M) Quantifications of Fzd6 staining along the medial and lateral junctions of OHCs. Numbers of OHCs scored are indicated on the bottom. Color keys for genotypes are indicated on the right. Ns, not significant.