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. 2021 Apr 16;9:649830. doi: 10.3389/fcell.2021.649830

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Copyright © 2021 Landin Malt, Clancy, Hwang, Liu, Smith, Smith, Hatley, Clemens and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Rac1 activation and Gsk3β inactivation on Dvl2 localization in Wls-deficient OC. (A–L) Flat-mounted E18.5 wild-type control (A,B), Rac1DA/+ (C,D), Gsk3β^cKO (E,F), Wls^cKO (G,H), Wls^cKO; Rac1DA/+ (I,J), and Wls^cKO; Gsk3β^cKO (K,L) OC stained for Dvl2 and ZO-1 as indicated. Arrows indicate Dvl2 crescents along the lateral borders of OHCs. Arrowheads indicate the inner pillar cell row. Lateral is up. Scale bar: 6 μm. (M) Quantifications of Dvl2 staining along the medial and lateral junctions of OHCs. Numbers of OHCs scored are indicated on the bottom. Color keys for genotypes are indicated on the right. Ns, not significant.