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. 2021 Apr 16;9:649830. doi: 10.3389/fcell.2021.649830

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Copyright © 2021 Landin Malt, Clancy, Hwang, Liu, Smith, Smith, Hatley, Clemens and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linescan analysis of junctional localization of Fzd6 and Dvl2 in outer hair cells. (A–F) Representative linescans of individual OHCs from E18.5 wild-type control (A), Rac1DA/+ (B), Gsk3β^cKO (C), Wls^cKO (D), Wls^cKO; Rac1DA/+ (E), and Wls^cKO; Gsk3β^cKO (F) OC stained for ZO-1, Fzd6, and Dvl2. For each genotype, a line was drawn parallel to the medial–lateral axis bisecting the OHC. Intensity profiles of each image channel were aligned along the distance axis. The lateral and medial junctions of the OHC were identified by peaks of ZO-1 staining and indicated by the blue and red dashed lines, respectively. Junctional Fzd6 and Dvl2 staining was defined by peaks in close proximity to the lateral or medial borders of the OHC.